The focus of the course is on understanding how humans walk and run. Topics will include kinematics, kinetics, neuromuscular activation patterns, energetics, and musculotendon mechanics. This course is taught in a Problem-Based Learning format, requiring students to integrate knowledge of muscle physiology, neuroscience, and biomechanics to analyze normal and pathologic human locomotion. Specific projects that students may work on include clinical gait analysis, lower limb prostheses, legged robots, and human exoskeletons.